Photodynamic Therapy (PDT) of Uveal Melanoma
Wachtlin J., Bechrakis N. E., Foerster M. H.
Dept. of Ophthalmology, Clinical Centre Benjamin Franklin, Free University, Berlin
Purpose: The induction of tumor necrosis in uveal melanoma by PDT with Verteporfin has already been shown in experimental animal models. The aim of this study was to evaluate this effect in human uveal melanomas.
Method: PDT with Verteporfin was performed in 4 eyes with uveal melanoma, 2 to 5 days before planned enucleation. Following treatment parameters were used: 10 min infusion with 6 mg/m2 Verteporfin per body surface area, light doses between 50 and 150 J/cm2, and diode laser wave length of 689 nm.
Results: At light doses of 100 J/cm2 or more depending on tumor pigmentation effects after PDT were detected on tumor tissue. Histologically vascular occclusion, thrombosis in tumor vessels and tumor cell necrosis up to 2 mm depth as well as invasion of macrophages and granulocytes were observed. In heavily pigmented melanomas no tumor necrosis was induced with the above mentioned parameters.
Conclusions: Depending on treatment parameters and tumor pigmentation, PDT is able to induce tumor necrosis in human uveal melanomas up to 2 mm depth. Based on these results it is possible that PDT can become an adjuvant treatment method for uveal melanoma.
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