|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
Update on PCO Research
Auffarth G. U.
Fifty years after the first implantation of an intraocular lens (IOL) by Harold Ridley, cataract surgery has become one of the most frequent and most successful surgical procedures in medicine. Even though, tremendous advances have been made especially during the last 10 to 15 years in terms of surgical techniques and improvement of implant technology, posterior capsule opacification (PCO) still remains a serious long-term complication. New methods for quantitative, objective evaluation of secondary cataract formation, as well as clinical and laboratory (especially autopsy eyes) studies have improved our understanding on how IOL design and material influence PCO. Sharp edge optic designs of IOLs of various materials have been shown to significantly reduce secondary cataract. Major advances in other areas of biotechnology and immunology including gene therapeutical methods offer totally new approaches for the future in the elimination of lens epithelium cells from the capsular bag. This survey gives an update on the pathology of PCO and influencing factors, as well as current and future means and trends to reduce or prevent PCO formation.