Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Concept of a Lamellar Keratoprosthesis Made of Polydimethylsiloxane

Berger E.1, Bochert A.1, Saedler J.1, Kreiner C. F.2, Guthoff R.1
1Department of Ophthalmology, University of Rostock, Germany; 2*Acri.tec GmbH, Lindenstr. 22/24; D- 16548 Glienicke, Germany

Purpose: In the last few years keratoprosthesis research was focused on evaluating potential haptic materials that may promote better biointegration. Tissue adhesion and fibroblast ingrowth into the keratoprosthesis haptic are important factors to ensure a permanent fixation of the prosthetic device and to withstand trauma. In disease with opacity of the anterior part of the cornea lamellar keratoprosthesis could be suffizient and solve problems like retroprosthetic membranes.
Method: Experiments were carried out with porous polydimethylsiloxane foam with a pore size ranging from 100 to 200 µm and a thickness of 200 µm and polytetrafluoroethylene with 63 to 78 µm pore size and 240 µm thickness. Biomaterial surfaces were modified by low pressure plasma treatment. Polymer samples were implanted in the corneal stroma of new zealand white-rabbits for a period of 8 weeks, half and one year. Biointegration in cornea, keratocytes ingrowth and collagen deposition were evaluated by histological methods.
Results: After implantation of porous polydimethylsiloxane foam and polytetrafluoroethylene neither acute nor chronic rejection were macroscopically seen. Histological examination showed no breakdown of the biomaterial up to two years but kerat

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