|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
Effect Of PEDF on the Proliferation of Bovine Retinal Pigment Epithelial Cells and Pericytes
Baldysiak-Figiel A., Lang G. K., Lang G. E.
Purpose: Diabetes mellitus and age-related macular degeneration (AMD) account for major causes of blindness in industrialized countries. In diabetic retinopathy, the proliferation of retinal endothelial cells is induced in part by progressive loss of pericytes, which is associated with the lack of the negative growth factor TGFß2. In AMD, the proliferation of choroidal endothelial cells is evoked by growth factor overproduction originating from proliferating retinal pigment epithelial cells (RPE). In this study we investigated the effect of PEDF, a potent serin protease inhibitor on RPE and pericytes.