Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Retinal Stem Cells in the Posterior Pars Plana of Rhesus Monkeys?

Friedemann T., Panda-Jonas S., Hayreh S. S.
Universitäts-Augenklinik Mannheim

Purpose: It has been generally assumed that the adult mammalian eye is devoid of retinal stem cells as self-renewing and multipotential cells. In a recent study, however, identification of a stem cell in the mouse eye was reported which represented a possible substrate for retinal regeneration (1). Examining rhesus monkey eyes, it was the purpose of the present light-microscopical study to look for a region in the pars plana area which could serve as nidus of retinal stem cells.
Method: The study included 10 rhesus monkeys. For 5 of these monkeys, experimental glaucoma had been produced by laser coagulation of the anterior chamber angle. Using light microscopy, different regions of the pars plana of the ciliary body were examined for regularity, cell size, nucleus size and hyperchromatosis.
Results: In the neighborhood of the ora serrata, the cells in the inner layer of the posterior pars plana usually seemed to be more than single layered. The nuclei were double as large as the nuclei in the peripheral retina and showed a hyperchromatosis. In direction to the anterior region of the pars plana and the pars plicata of the ciliary body, the cells in the inner layer of the pars plana epithelium were clearly single layered, the nuclei were smaller and showed less hyperchromatosis than the cells in the posterior region of the pars plana. There were no differences in the anatomy of the posterior pars plana region between the n

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