Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Experimental Surgery on Active Intraocular Implants

Alteheld N., Rössler G., Walter P.
Zentrum für Augenheilkunde der Universität zu Köln, Cologne, Germany

Purpose: Active implants represent a new group of intraocular implants. To ensure the feasibility, biocompatibility, functionality of such systems for a human application operation procedures have to be ensured in animals.
Method: In the rabbit and the cat combined operations of the anterior and the posterior segment were carried out for the principle feasibility of implantation of such complex structures. Intraocular pressure sensors and intraocular vision aids (IOVA) were implanted into the capsular bag of rabbits after standard phacoemulsification. Complex Retina Implant (RI) systems were positioned in the capsular bag after phacoemulsification. After vitrectomy the retina stimulators themselves were fixated on the central retina.
Results: The implantation of active intraocular implants could be realised successfully. Hereby the preconditions for investigations on biocompatibility and functionality were provided. For the Retina Implant system a constant attachment of the electrode-array on the retina`s surface could only be achieved with mechanical helps as heavy vitreous substitute or retina pins. The implantation of intraocular pressure sensor systems was possible with small incision techniques and with foldable implant-systems.
Conclusions: It could be demonstrated that even complex intraocular systems can be relatively gently implanted into the globe with modification of established operation t

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