SupraDescemetic Synthetic Cornea (sDSC) Preliminary Results of a Novel Non-penetrating Keratoprosthesis in the Rabbit Model
Stoiber J.1,2, Fernandez V.1, Kaminski S.3, Lamar P. D.1, Lacombe E.4, Duchesne B.5, Parel J.-M.1,5,6
1Bascom Palmer Eye Institute, Ophthalmic Biophysics Center Univ. of Miami, USA; 2Landesklinik für Augenheilkunde und Optometrie, Private Medizinische Universität Salzburg, Austria; 3Universitätsklinik für Augenheilkunde und Optometrie, University of Vienna (AKH), Austria; 4Rothschild Foundation, Paris, France; 5CHU Sart-Tilman, University of Liege, Belgium; 6University of Paris XI Hotel-Dieu Hospital, France
Purpose: To show feasibility and biocompatibility of a novel non-penetrating keratoprosthesis (supraDescemetic Synthetic Cornea, sDSC) in a rabbit model.
Method: A new surgical technique was developed to implant the keratoprothesis (7 mm diameter, 450mm thick optical zone) on top of a bare Descemets membrane (DM). 4 different materials were tested in this series: hydrophobic PMMA, hydrophilic pHEMA-MMA26, pHEMA-MMA34 and pHEMA-NVP75. The device was successfully implanted in healthy eyes of 17 New Zealand White rabbits and followed for up to 7 months to date. 7 rabbits were selected for histological evaluation. In 16 rabbits an ocular surface injury was created by application of 1-heptanol onto the cornea and surgical removal of the limbus, leading to vascularisation and scarring.
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