Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Progression of Atrophy and Visual Loss in Geographic Atrophy due to Age-related Macular Degeneration (AMD)

Bindewald A.1, Sieber H.1, Schmitz-Valckenberg S.1, Jorzik J. J.1, Miller D. W.1, Schuldt A.2, Keilhauer C.3, Weinberger A.4, Wolf S.5, Mansmann U.2, Holz F. G.1 for the FAM-Study Group
Dept. of Ophthalmology1 and Institute for Medical Biometry2, University of Heidelberg, Depts. of Ophthalmology University of Würzburg3, RWTH Aachen4, University of Leipzig5

Purpose: Geographic atrophy (GA) is a common cause for severe visual loss in advanced AMD. We determined the natural history of patients with GA based on delineation of atrophic patches and their variation over time in fundus autofluorescence (AF) images.
Method: 86 eyes of 57 patients with uni- or bilateral GA were followed on average over 2.9 years (interquartil distance IQD 1.3-4.3) in a prospective longitudinal study in an arm of the multicenter FAM-Study. Fundus AF images were obtained with a confocal scanning laser ophthalmoscope (cSLO, exc. 488 nm, em >500 nm, Heidelberg Retina Angiograph, Heidelberg Engineering). GA areas were identified based on their markedly decreased AF-signal and quantified with an automated image analysis method (Global Lab Image/2) or by manual outlining. Bestcorrected visual acuity was dermined usind ETDRS-charts.
Results: Atrophy enlarged by 1.44 mm2 per year (IQD 0.6-1.8) in an alm


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