Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Vaccinia-Virus Infection of the Eye

Carstens J., Kopf H., Kuhn H. J., Müller M., Schworm H. D., Fankhauser F.
Eye-clinic Dessau

Purpose: According to WHO information systemic infection with Variola virus (Smallpox) is elimitated since 1977 but gains increasing relevance due to the general geopolitical situation. Since termination of the vaccination program no further associated diseases have been noted.
Method: We report the case of a 41 y old male who inoculated vaccinia virus solution during professional handling in the vaccine production process.
Results: The patient noted 4 days after inoculation nasal conjunctival injection. Initial treatment started at day 6 after inoculation due to increasing edema and swelling of the lids. At day 9 the patient was admitted to our facility. The clinical status revealed pus filled lesions at the lid margind with edema and conjunctivits. At day 11 an additional keratopathia with central epithelial defect occurred. Initial treatment has been performed by means of Zoliparin ointment as well as TFT eye drops. Vaccinia virus infection has been confirmed by PCR. Healing of the superficial leasions was noted starting from day 20.
Conclusions: Vaccination at large scale is being discussed presently in Germany. The stockpile of the vaccine is currently about to be enlarged. Therefore the statistical risk of direct or secondary infection of the eye and its adnexe is increased. As demonstrated the clinical significance for the people as well as the institution involved is significant. Vaccinia virus infection of the eye has be

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