Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Implantation of a Complex Retinal Prosthesis Consisting of Combined Anterior and Posterior Segment Islands is a Challenging Surgical Procedure

Gerding H.1, Uhlig C. E.1, Taneri S.2, Busse H.1
1Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Münster
2Zentrum für Refraktive Chirurgie Münster

Purpose: Several cooperative groups are aiming to develop epiretinal prostheses that may restore orientation by the transmission of image information to surviving retinal ganglion cells in patients with retinal degenerations. The majority of approaches are focusing on "two island implants" consisting of IOLs connected via microcable with posterior microcontacts. In this study the clinical feasibility of implantation was tested.
Method: Two different implants were used in rabbits: 1. posterior segment microcontact foils connected with IOL´s, and 2. final-version implants. All devices were electrically inactive. Principle steps of procedures were: phacoemulsification, vitrectomy, posterior capsulotomy, guidance of microcontacts to the posterior pole, and stabilization of microcontact foils by newly designed hybrid microtacks. In five cases a corneoscleral/corneal approach was used, in two cases an open sky implantation was applied. Follow up covered 3-12 months including funduscopy, photography, echography, and electroretinography. Post mortem evaluation was performed by standardized macropathological, histological and immunhistochemical examinations.
Results: During implantation an intensive anter


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