Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Intraocular Light Stimulation by Intraocular Vision Prostheses in Animal Experiments – First Results

Roessler G., Alteheld N., Walter P.
University of Cologne, Dep. of Ophthalmology

Purpose: The IOVA research group developed an intraocular microdisplay to be implanted in eyes affected by heavy injuries or severe inflammations where penetrating keratoplasty failed to restore sight, so surgical recovering of the anterior segment is not required anymore. First experiments included the implantation of LEDs being incapsulated in intaocular lenses (IOL-LED) to prove tolerability and function of intraocular displays.
Method: The IOL-LEDs were implanted into the sulcus or the capsular bag of the removed natural rabbit lens. In the meantime energy supply occurs wireless whereas first experiments used cables for electrical power supply. For proving tolerability and function of the incapsulated displays several examinations including funduscopy, electroretinogram (ERG) and visually evoked potentials (VEP) as well as histological examinitions were performed.
Results: Retinal stimulation by IOL-LEDs does not cause severe complications. Cortical potentials as well as retinal responses in ERG could by triggered by LED-stimulation.
Conclusions: First experiments with simple IOL-LEDs show a good tolerability for incapsulated microdisplays as well as cortical activations can be triggered.


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