Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Non Invasive Polarimetric Measurement of Glucose Concentration in the Anterior Chamber of the Eye

Rawer R.1, Stork W.1, Kreiner C. F.2
1Universität Karlsruhe, Institut für Technik der Informationsverarbeitung (ITIV); 2Acri.Tec GmbH, Glienicke

Purpose: Diabetes Mellitus is one of the most common diseases in the industrialized countries as well as in border countries. One of the key technology for diabetes therapy is a semi-continuous monitoring of the blood glucose level of the diabetic. Optical measurement techniques promising good results bear the potential for a high patient compliance for more frequent measurements compared to skin perforating techniques.
Method: Due to its excellent optical properties the anterior chamber and the contained aqueous humor offer promising features for non invasive in vivo Glucose measurements. However, a number of strongly limiting factors like the precise optical properties of the eye, laser safety regulations and subconscious eye movements during the measurement itself have to be considered for future in vivo application.
Results: This article presents a polarimetric measurement system, which utilizes the optical activity of the glucose molecule for measurements of the glucose concentration of the Aqueous Humor. In addition the special limitations and conditions which have to be considered for in vivo glucose measurement at the human eye with special concern of the impact of typical eye movements during a measurement, and laser safety regula

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