Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Diurnal Rhythms of Serum Melatonin in Patients with Progressive Retinal Dystrophies

Gerding H.1, Trilling I.2, Timmermann M.3, Uhlig C. E.1, Thelen U.1, Lerchl A.4
1Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Münster
2Klinik für HNO, Kreisklinik Parsing, München
3Augenklinik der Städtischen Krankenanstalten Krefeld
4School of Engineering and Science, International University Bremen

Purpose: Disturbances of the subjective day/night-rhythm are frequently reported by patients with hereditary retinal dystrophies. It was the aim of this study to analyze different physiological parameters normally presenting circadian rhythms in such a group of patients
Method: 11 probands (4 male, 7 female, age range 25 - 61 years) suffering from progressed retinal dystrophies were enrolled in this study. Different parameters were monitored during a complete and standardized 24-hour period in a controlled clinical situation. Blood samples were taken every two hours. Melatonin was quantitatively analyzed using a standardized RIA.
Results: Serum concentrations of melatonin presented a typical diurnal rhythm in all probands enrolled in this study. The nightly acrophase of melatonin occurred within the normal time range (samples 0.00 - 4.00 am). During lighted daytime a typical through of melatonin levels was found without exception. No signs of desynchronization or dissociation of the diurnal rhythm of melatonin were found in analyzed periodograms. 3


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