Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


Hotelbuchung
   Hotel Registration
Grußwort
   Welcome address
Beteiligte Gesellschaften
   Societies involved
DOG Information
   DOG Information
Eröffnung des Kongresses
   Opening Ceremony
Preise
   Awards
Ablauf der Tagung 2003
   General overview of congress
Lageplan der Räumlichkeiten
   Map of Congress Center
Wissenschaftliche Themen
   Scientific topics
Symposien
   Symposia
Wissenschaftliches Programm
   Scientific program
Posterpräsentationen
   Poster Presentation
Kurse
   Courses
Begleitende Veranstaltungen
   Accompanying program
Arbeitssitzungen
   Working sessions
Rahmenprogramm
   Social program
Allgemeine Informationen
   General Information
Autorenindex
   Index of Authors
Industrieaussteller
   Commercial exhibitors
Sponsoren
   Sponsors
Impressum



DOG Homepage


Abstract
Abstract

Adjuvant Decorin Therapy for Wound Healing Suppression after Filtrating Glaucoma Surgery

Grisanti S., Szurman P., Ziemssen F., Warga M., Denk P. O., von Eicken J., Bartz-Schmidt K. U. 
Center of Ophthalmology, Department I, Eberhard-Karls University Tübingen

Purpose: To evaluate the antifibrotic effect of subconjunctival injection of Decorin after glaucoma filtering surgery in a rabbit model.
Method: Rabbits (ChBB:CH; n=15) received filtering surgery on the right eye and were divided into three groups (n=5): group 1 without adjuvant therapy, group 2 with 0.04 mg Decorin and group 3 with 0.1 mg Decorin. Rabbits in the groups 2 and 3 received subconjunctival injection of Decorin 15 min before surgery and in the four successive postoperative days. Operative procedure comprised: preparation of a 2.5 x 2.5 mm scleral flap, trepanation with a 1.5 mm trephine and subsequent iridectomy. Antifibrotic efficacy was established by clinical response and histological examination. A successful reduction of the intraocular pressure (IOP) was defined as IOP-ratio (between the treated experimental right eye and the left eye) < 0.8. After 2 weeks, the eyes were enucleated and processed for histological examination.
Results: In group 1 intraocular pressure exceeded a ratio of 0.8 at 7 days postoperatively, while groups 2 and 3 maintained a pressure ratio less than 0.8 during the follow up time of 2 weeks. After 14 days eyes with group 2 disclosed a mean ratio of 0.75±~.09 and group 3 a ratio of 0.58±0.11. Histology in control eyes disclosed a mar


Zurück | Back