Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Birdshot Choroidopathy: a Retrospective Study

Birk U., Biester S., Siepmann K., Deuter C. M. E., Stübiger N., Zierhut M.
University Eye Hospital, Dept. I, Tübingen

Purpose: Birdshot Choroidopathy is a rare form of posterior uveitis belonging to the white-dot-syndromes. We report on clinical manifestation and therapy in 9 patients.
Method: In a retrospective study data on epidemiology, first onset, clinical course, diagnosis and treatment of the disease were raised.
Results: We examined 9 patients (7 female, 2 male) presenting typical changes at the posterior segment. The age of the patients was 40 to 68 years (mean 52 years). The time between date of onset and diagnosis was up to one year in two cases and up to five years in another two patients. Associated systemic diseases were diabetes (2), arterial hypertension (2), a benigne gammopathy (1) and drug-induced lupus erythematodes (1). At first contact we found an inflammation of the anterior chamber in 3 patients and endothelial precipitates in one patient. In 6 patients a vasculitis was demonstrated by fluoresceine angiography. Additional complications were epiretinal gliosis (n=3), macular oedema (n=4) and a choroidal neovascularisation membrane in both eyes (n=1). All patients were HLA-A 29 positive. Three of four perimetries showed pathological findings, all of them with relative scotomas. Seven patients were treated inicially with Prednisolon. There was no progress of disease even without therapy in 2 patients. In 6 of the 7 patients there was no improvement or stabilization of inf

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