Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Long-term Follow-up after PDT in Patients with Postinflammatory CNV

Gerth C., Spital G., Spital S., Lommatzsch A., Pauleikhoff D.
Dep. of Ophthalmology, St. Franziskus-Hospital, Münster

Purpose: CNV of the classic type represents a common complication of choroidal inflammatory diseases. In this case PDT-treatment was recently shown to have a beneficial effect for visual acuity. Nevertheless because of the tendency for recurrency of CNV in these different inflammatory diseases the long-term prognosis and visual outcome after initial successful treatment remains uncertain and is topic of this study.
Method: The study included 36 eyes of 32 patients (24 female, 8 male, 18-51 y., mean 36.3y.) with classic subfoveal CNV (FLA and ICG-angiography) and diagnosis of a POHS (23 eyes), a multifocal choroiditis (6 eyes), a punctate inner choroidopathy (3 eyes) or other inflammatory diseases (4 eyes). The initial visual acuity was between 6/60 and 40/60, median 20/60. A usual PDT with visudyne was performed. FA and ICG was repeated every 6 weeks after PDT, in order to evaluate the activity of the CNV. If an increased staining and leakage of the membrane after three months of the previous PDT was seen, the PDT was repeated. PDT was also repeated in case of other localisation of a new CNV manifestation extending under the fovea.
Results: After PDT (follow up >12 mo ) improvement in the visual acuity (>3 lines ETDRS) was seen in 30%, stabilization of visual acuity (Zurück | Back