Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Multifocal Oscillatory Potentials in Patients with Vascular Ocular Disease

Jägle H., Stepien J., Kurtenbach A.
University Eye Hospital Tuebingen, Germany

Purpose: The aim of this project was to assess retinal function in patients with various vascular ocular diseases using multifocal ERG (mfERG). Their ERG results were compared with those from age-matched control subjects.
Method: The multifocal stimulus was generated on a Sony Triniton 21” monitor with a resolution of 1024 x 768 pixels. It consisted of 103 hexagons subtending the central 84° x 75° of the retina at a viewing distance of 18 cm. The continuous mfERG recordings were obtained and analyzed using a Grass Instruments amplifier and the VERIS (4.1) system. We assessed cone function using standard ISCEV black (0.04 cd/m2) - white (122 cd/m2) stimulus and inner retinal function using black – white multifocal oscillatory potentials (mfOPs). The results from the affected eyes were compared with the fellow eyes and with recordings from normal subjects.
Results: We recorded mfERGs and mfOPs in a series of patients with branch retinal vein or artery occlusion, as well as in patients with papillitis or anterior ischaemic optic neuropathy. Our results show topographical alterations in the mfERG of the affected eye which define both ischaemic and non-ischaemic retinal areas corresponding to fundal changes. MfOPs also showed reduced or extinguished amplitudes of response components in the affected areas.
Conclusions: MfERG is a sensitive method for delineating subfunctional retina

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