|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
Macular Pigment and Antioxidative Prophylactic Strategies
van Kuijk F. J. G. M.1, Trieschmann M.3, Fitzke F.2, Bird A. C.2, Pauleikhoff D.3
Purpose: To review strategies for further investigation of the role of Macular pigment (MP) in prevention of Age Related Macular Degeneration (ARMD). MP was first described as a yellow spot in the centre of the human eye, and was later identified as two xanthophyll carotenoids, lutein and zeaxanthin. Lutein and zeaxanthin not only accumulate in the macula, but are also concentrated in the photoreceptor outer segments of the peripheral retina. The mechanism by which MP might influence ARMD is poorly understood. It would act as a blue light filter, thus reducing oxygen radical formation in the underlying photoreceptors.