Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Visual Evoked Potentials (VEP) in Patients with Various Steps of Thyroid Ophthalmopathy

Pojda S. M., Pojda-Wilczek D., Plech A. R., Makowiecka-Obidzińska K., Herba E.
Department of Ophthalmology and Eye Clinic Silesian Medical University, Bytom/PL

Purpose: To estimate the diagnostic value of VEP for necessity for treatment of the thyroid ophthalmopathy.
Method: 66 patients (132 eyes) aged from 45 – 72 were examined due to vision problems origin from Graves disease. The patients were divided in 6 groups according to Grave’s score ( 0-VI) classification. The patients were treated with systemic steroids, some of them were operated. Pattern, transient (pVEP) and flash VEP (fVEP) were performed according to ISCEV standards. LKC (USA) equipment, UTAS E-2000 program was used. P100 amplitude and latency were calculated.
Results: We have found that the orbital pathologic changes causes the first disturbances of VEP were from III step of Grave’s disease. The P100 latences were delayed and its amplitudes decreased or even abolished in VI step. The values of P100 amplitudes in both pattern and flash stimulations improved when the visual acuity was improved, but the prolongation of the latencies always was maintained. In some patients with good visual acuity and out of any complications, but with intraocular hypertension the VEP changes were also observed.
Conclusions: The VEP studyin patients with Grave’s disease is very helpful for making a propter decision for initiale of early treatment of Grave’s ophthalmopathy.

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