Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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MMC Application for Haze Removal after Photorefraktive Keratectomy (PRK)

Ardjomand N., Fellner P., Vidic B.
Dept. of Ophthalmology, Graz/A

Purpose: Mitomycin C (MMC) is an antimetabolit inhibiting scar formation by suppressing DNA synthesis. MMC has been used in glaucoma surgery successfully for years and first results with this antimetabolit seem also to be promising in refractive surgery.
Method: 6 patients who developed haze grade 2-3 and reduction of visual acuity after PRK underwent PTK with with ablation depht of 10-15 mm. The epithelium was treated at first with 20% ethanol for 30 seconds and then peeled similar to LASEK. MMC 0.02% was applied for 2 minutes on the ablation area after excimer laser treatment. At the end the cornea was rinsed with 40 ml of 0.9% NaCl and the epithelium put back on the stroma. AT the end, a silicone contact lens was applied for 3 days. Post operative treatment included Tobradex AT® and hyaluronic acid 0.25%. Follow-up time is 2 months.
Results: The patients did not complain about pain in the early postoperative period. Increase of visual acuity was observed and the cornea did not develop haze during the follow-up period. No complications were seen.
Conclusions: PTK in combination with MMC 0.02% for 2 minutes is an efficient method to treat haze formation after PRK.

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