Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Corneal Woundhealing after hyperopic PRK and LASIK

Hammer T.1, Gießler S.3, Duncker G. I. W.1, Peschke E.2
1Department of ophthalmolgy, 2institute of anatomy and cellbiologie, University Halle-Wittenberg; 3Vista clinic, Binningen/CH

Purpose: Purpose of this study was to investigate the influence of different postoperative treatments on the wound healing reaction in the anterior stroma after PRK and in the interface area after LASIK with morphological and immunohistochemical methods on the light- and electronmicroscopical level.
Method: 72 corneal buttons of refractively treated rabbit eyes underwent different postoperative eye drop regimes with antibiotics and/or steroids or additional UV-B irradiation. 6 months postoperatively morphological and immunohistological investigations were performed by light- and transmission electron microscopy. As immunohistochemical markers were tested collagen type III, IV and VII, fibrillin-1, cytokeratin, alpha-smooth-muscle actin and laminin.
Results: PRK-eyes showed interdigitations between the epithelia and the anterior stroma. Histological detectable wound healing reactions are visible in this area. LASIK treated eyes showed only minor changes between epithelia and stroma in the cutting region. Only a slightly increase in deposits of fibrillar extracellular matrix components were detectable in the interface region. UV-B irradiation stimulates the wound healing reaction and different postoperative treatments cause different immunohistochemical rea


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