Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Complications after Photodynamic Therapy

Schnurrbusch U. E. K., Jochmann C., Einbock W., Nestler A., Domke N., Mößner A., Wolf S.
Klinik und Poliklinik für Augenheilkunde, Leipzig

Purpose: To evaluate the incidence of complications of photodynamic therapy (PDT) with Verteporfin (Visudyneâ) subfoveal choroidal neovascularisations (CNV) secondary to age-related macular degeneration (AMD) and pathologic myopia (PM).
Method: Consecutive records of all patients with AMD and PM treated with PDT between 3/2001 and 3/2003 at the Eye Clinic Leipzig were reviewed for complications. Complications included infusion-related back pain, extravasation at the infusion site, acute severe vision decrease of more than 3 ETDRS lines in the treated eye within 7 days after treatment, extensive retinal capillary non-perfusion, or extensive hemorrhages.
Results: We included 233 patients in the study in whom 430 PDt treatment sessions were performed. Infusion-related back pain was reported in 5 (2%) patients. Acute severe vision decrease was documented after 4 (0,9%) PDT treatments within 7 days after treatment. In three eyes visual loss was related to extensive intra- and subretinal hemorrhages. One patients with PM experienced an acute visual loss without clinical or angiographic abnormalities. In two additional eye extensive intra- and subretinal hemorrhages were documented without acute visual loss. Adverse events due to extravasation or photosensitivity reactions were not reported among our patients.
Conclusions: Complications associated with PDT ar

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