|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
Microsurgical Therapy of Defective Corneal Regeneration
Seitz B.1, Sauer R.1, Langenbucher A.1, Hofmann-Rummelt C.1, Wenkel H.1, Kruse F. E.2
Purpose: Defective corneal regeneration can occur in ulcers of infectious (herpetic, bacterial, fungal), rheumatoid or neuroparalytic origin, in limbal stem cell deficiency after (chemical) burns, Fuchs-Stevens-Johnson syndrome or aniridia, and after penetrating keratoplasty. Recurrent corneal erosion syndrome represents a mild variant, in which adhesion complexes between epithelium and stroma are not sufficiently regenerated (qualitatively or quantitatively). The purpose of this lecture is to critically demonstrate surgical therapy options of defective corneal regeneration, that may be necessary if conservative medical approaches (unpreserved artificial tears, gels and ointments (w/o pressure patch), vitamin A or hyaluronic acid containing medications or autologous serum) fail.