|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
Medical Approaches for Corneal Wound Healing Modulation
In the cornea regeneration and repair are determined by the specific properties of epithelial keratinocytes, stromal keratocytes and endothelial cells. Of these only the epithelium is capable of true regeneration without repair (restitutio ad integrum). This involves proliferation, migration and differentiation of epithelial cells. These are modulated by cytokines such as growth factors, interleukins, as well as vitamins. They also involve non-structural extracellular matrix proteins (e. g. fibronectin) and proteases. Biochemical and biophysical mechanisms, as in ocular surface disease due to aqueous deficient dry eye or rheumatoid sterile corneal ulceration compromise the corneal wound healing reaction. Specific control of the underlying pathologic process, avoiding therapy associated toxicity and supporting corneal cellular regeneration by means of nutrient substances are the main goals in this situation. This presentation outlines the current medical options of modifying corneal wound healing, with special emphasis on the epithelium.