Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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New Insights in Uveal Melanoma Biology and their Potential Impact on Clinical Praxis

Anastassiou G.1, Tschentscher F.2, Hüsing J.3, Zeschnigk M.2, Bornfeld N.1
1Department of Ophthalmology, 2Institute for Human Genetic, 3Institute for medical Informatic, Biomathematic and Epidemiology; University of Essen

According to the results of microarray analyses it could be shown that based on the gene expression profiles two distinct uveal melanoma entities exist. These two entities correlated almost perfectly with the chromosome 3 status. As already known from many independent studies metastatic disease almost exclusively develops from tumours which have a loss of one copy of chromosome 3 (monosomy 3). None of the investigated clinical and histopathological features showed such a correlation with the two entities. According to these results, to date many patients with uveal melanoma are treated though the tumour is not threatening their lives. The status of chromosome 3 can only be detected in tumour tissue. Shouldn’t we perform that routinely in any patient who is treated either by enucleation or tumour excision and plan adjuvant therapy according to the results? Shouldn’t we even by small-medium size tumours, which are treated by irradiation, perform more diagnostic (e.g., biopsy for chromosome 3 status evaluation) and as a result less treatment? Alternative non invasive procedures to identify the two entities based on the results of the microarray analyses will be also discussed.

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