Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


Hotelbuchung
   Hotel Registration
Grußwort
   Welcome address
Beteiligte Gesellschaften
   Societies involved
DOG Information
   DOG Information
Eröffnung des Kongresses
   Opening Ceremony
Preise
   Awards
Ablauf der Tagung 2003
   General overview of congress
Lageplan der Räumlichkeiten
   Map of Congress Center
Wissenschaftliche Themen
   Scientific topics
Symposien
   Symposia
Wissenschaftliches Programm
   Scientific program
Posterpräsentationen
   Poster Presentation
Kurse
   Courses
Begleitende Veranstaltungen
   Accompanying program
Arbeitssitzungen
   Working sessions
Rahmenprogramm
   Social program
Allgemeine Informationen
   General Information
Autorenindex
   Index of Authors
Industrieaussteller
   Commercial exhibitors
Sponsoren
   Sponsors
Impressum



DOG Homepage


Abstract
Abstract

Endoresection Following Proton Beam Irradiation of Large Uveal Melanomas

Foerster M. H.1, Bechrakis N. E.1, Höcht S.2, Martus P.3, Kluge H.4 
1Augenklinik, 2Strahlentherapie, 3Statistik und Epidemiologie, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin; 4Hahn-Meitner Institut, Ionenstrahlenlabor, Berlin

Purpose: Large uveal melanomas have an unfavourable prognosis with regard to visual preservation and eye retention, due to the high incidence of radiation and tumour necrosis induced complications. Endoresection of tumours located close to the optic nerve and/or fovea after proton beam irradiation, is an alternative approach, aiming to reduce the incidence of ocular morbidity caused by tumour necrosis after radiotherapy alone.
Method: 32 patients with large uveal melanomas (mean tumour thickness: 9,1 mm, mean tumour volume: 0,77 cc), received a primary proton beam irradiation (60 CGE) and underwent subsequent endoresection via a 3-port pars plana vitrectomy. The median pre-treatment visual acuity was 0,2. The mean follow-up was 13,9 months.
Results: The postoperative visual acuity after 12 months was 0,12 (median , mean visual acuity loss 0,08). The probability of developing radiation retinopathy or papillopathy within the first year after treatment was 35% and 28% respectively and the probability of enucleation was 9% within the first postoperative year. No tumour recurrences were observed and two patients developed liver metastases.
Concl


Zurück | Back