Factors Influencing Visual Acuity after Intravitreal Triamcinolone Acetonide as Treatment of Exudative Age-related Macular Degeneration
Degenring R. F., Kreissig I., Jonas J. B.
Dept. of Ophthalmology, Faculty for Clinical Medicine Mannheim, University Heidelberg
Purpose: To evaluate factors influencing change in visual acuity after intravitreal injection of triamcinolone acetonide as treatment of progressive exudative age-related macular degeneration
Method: The prospective interventional clinical case-series study included 99 eyes (94 patients) showing progressive exudative age-related macular degeneration with occult (n=61eyes), minimally classic (n=18), predominantly classic (n=1), or totally classic (n=8) subfoveal neovascularization. All patients received an intravitreal injection of 25 mg of triamcinolone acetonide. Follow-up was 8.5 ± 4.7 months (median, 7.3 months; range 3.1 24.5 months).
Results: An increase in best visual acuity of at least one Snellen line was found for 63 (63.1%) eyes. Correspondingly, visual acuity increased significantly (p<0.001) from 0.17 ± 0.13 to 0.22 ± 0.17 after the injection. Postoperative increase in visual acuity was significantly and negatively correlated with preoperative visual acuity (correlation coefficient: -0.49; p<0.001). Gain in visual acuity was significantly (p=0.009) higher if preoperative visual acuity was less than 0.08 (gain: 3.2 ± 2.9 Snellen lines) than as if preoperative visual acuity ranged between 0.08 and 0.20 (gain: 1.2 ± 2.2 Snellen lines). Change in visual acuity was significantly (p=0
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