Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Prevalence of Sleep Apnea in Patients with Low Tension Glaucoma

Lämmer R.1, Wiest G. H.2, Michelson G.1
1Augenklinik mit Poliklinik, 2Medizinische Klinik I mit Poliklinik, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen

Purpose: In approximately 15% of all patients with OAG no IOP values above the statistical border line of 21 mmHg can be proven. In order to explain the characteristic optic disc changes and visual field loss, several risk factors are postulated primarily concerning a disturbed perfusion. Also sleep apnea syndrome (SAS) is discussed as a risk factor. However in the literature results for answering the question of the frequency of SAS in patients with low tension glaucoma (LTG) are rare.
Method: 60 patients with clinically proved diagnosis of LTG were examined by ambulatory cardiorespiratory polygraphy for obstructive sleep disorders. In case of a pathological result diagnosis were confirmed by poly-somnography. Obstructive sleep apnea (OSA) was diagnosed on the basis of respiratory disturbance index (RDI) > 5.
Results: In 8 of 60 patients (13,3%) OSA was diagnosed. RDI was 18,3 ± 8,4 in patients with OSA and 0,6 ± 1,4 in patients without OSA (p<0,001). O2 Desaturation Index of 16,9 ± 9,9 was seen in opposite to patients without SAS of 2,5 ± 3,4 (p<0,001). Patients with OSA did not differ significantly concerning age (61 ± 4 vs. 60 ± 9), sex, and body mass index (26.5 ± 2.8 vs. 24,5 ± 3.4).
Conclusions: In our examinations obstructive sleep apnea in patients with low tension glaucoma shows prevalence in the upper range as expected in the population on basis of the epidemiological data.

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