|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
Alkylphosphocholines Inhibit Proliferation and Contraction of Human Retinal Pigment Epithelial Cells
Eibl K. H., Schoenfeld C., Neubauer A. S., Priglinger S., Kampik A., Welge-Lüßen U.
Purpose: Proliferative Vitreoretinopathie (PVR) is a major complication in retinal detachment surgery. Proliferation and contraction of retinal pigment epithelial cells (RPE) in the vitreous seems to be fundamental in PVR membrane formation and subsequent retinal detachment. So far, there is no treatment in routine clinical use to prevent this condition. The aim of our study was to test Alkylphosphocholines (APCs) for their antiproliferative and anticontractile effect on human RPE cells in vitro and to elucidate their mechanism of action.