Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Follow-up in Patients with Choroideal Neovascularisations and Angioid Streaks

Knur K. K., Schnurrbusch U. E. K., Wolf S.
Klinik und Poliklinik für Augenklinik, Universität Leipzig

Purpose: Angioid streaks are a disease of ‚Bruchs membrane' which is often associated with a general syndrome. The appearance of choroideal neovascularisations (CNV) and progressive pigmentepithelium atrophy may cause a severe loss of visual acuity. We examined patients with CNV due to angioid streaks to evaluate effects of photodynamic therapy (PDT) or laser photocoagulation.
Method: Included into study were patients with CNV due to angioid streaks diagnosed by angiography. Examinations included ETDRS-visiual acuity, funduscopy, fluoresceinangiography and indocyanine green angiography. Fundus photography and angiography are used for staging CNV's into sub- or extrafoveal localisation. Based on the angiographic features therapeutic strategy was determined.
Results: Nine patients (five female, four male) aged 35-69 with CNV (six extrafoveal, three subfoveal) were included. Four of them were treated with laser photocoagulation, three eyes received PDT with Verteporfin. Two eyes were followed without therapy. In total 15 treatment sessions were performed, seven PDT sessions and eight focal laser photocoagulation treatments. The mean of the follow up period were 16,3 months. Initial visual acuity at baseline ranged between 20/60 and 20/30. At the last follow-up visit visual acuity ranged between 20/400 and 20/30. During the study period three patients experienced a moderate loss of visual ac

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