Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

The Nature of the 'Negatve ERG' and its Correlative in Multifocal ERG Recordings

Miyake Y.
Department of Ophthalmology, Nagoya University, Nagoya, Japan

The negative configulation in scotopic bright flash ERG indicates the lower b-wave than a-wave, which is seen in patients with functional disturbance of the second order neuron, such as some kinds of CSNB, X-linked retinoschisis, and so on. In cone visual pathway of such patients, the long-flash cone ERG is requested to evaluate the function of ON- and OFF-pathway separatedly. The optimal conditions for recording multifocal ON-OFF responses will be described. I want to emphasize why such evaluation is important, using complete CSNB which is a model disease of the selective defect of rod and cone ON- pathway. In addition, some interesting clinical cases will be introduced to demonstrate ON- or OFF-dominant macula which is shown by multifocal ERG.


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