Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Multifocal ERG: Age Dependence of the Functional Topography

Langrova H.1,2, Seeliger M. W.2
1University Eye Hospital, Hradec Kralove, Czech Republic. 2Retinal electrodiagnostics research group, Dept. of ophthalmology II, Tübingen, Germany.

Purpose: To assess the age dependence of peak amplitudes and implicit times of multifocal electroretinograms in normal subjects.
Method: 59 normal subjects aged 10-70 years were split into six groups, one per decade, with about ten subjects each. Subjects were examined with the Visual Evoked Response Imaging System (VERIS) using a resolution of both 61 and 103 hexagons within a 30° visual field. Peak amplitudes and implicit times of first and second order kernels were determined for all elements, and medians and percentiles were calculated for each group separately. The medians for all 61 or 103 locations were used to construct a topographical image of peak P1 amplitude and implicit time. The Mann-Whitney test was used for the statistical evaluation of differences between groups.
Results: As expected, the first order kernel data showed a continuous loss of amplitude with age, accompanied by a steady rise in peak implicit time. The typical topographical differences across the retina, however, were preserved in all age groups. The second order kernel data also featured a loss of amplitudes with age, but initially increased from the first (10-20) to the second age group (20-30).
Conclusions: Our data reveal several features of the age dependence of multifocal ERG recordings. There was a steady, gen

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