Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Anatomic Relationship between Lamina Cribrosa, Intraocular Space and Cerebrospinal Fluid Space

Berenshtein E.1, Holbach L.2, Jonas J. B.1 
1Universitäts-Augenklinik Mannheim; 2Universitäts-Augenklinik Erlangen-Nürnberg

Purpose: The lamina cribrosa as the bottom of the optic nerve head acts as a pressure barrier between the intraocular space and the retrobulbar space of the optic nerve. It may have importance for the pathogenesis of ocular diseases related to intraocular pressure and / or cerebrospinal fluid (CSF) pressure, such as the glaucomas. The purpose of the present study was, therefore, to study the anatomical relationship between the lamina cribrosa, the intraocular pressure space, and the retrobulbar cerebrospinal pressure space.
Method: The study included 55 globes enucleated due to malignant choroidal melanoma (n=42) without involvement of the optic nerve (control group), or enucleated due to painful absolute secondary angle-closure glaucoma (n=13) (glaucoma group). Anterior-posterior sections through the pupil and the optic disc were histomorphometrically evaluated.
Results: In the glaucoma group compared with the control group, the lamina cribrosa was significantly (p=0.001) thinner, the part of the outer lamina cribrosa surface directly exposed to the CSF space was significantly (P=0.001) wider, and the shortest distance between the intraocular space and the CSF space was significantly (p<0.05) shorter. The location of the posterior lamina cribrosa surface directly exposed to t


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