Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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A Histopathological Evaluation of the Retinal Surface and the ILM after the Use of Glucose 5% diluted Indocyanine Green

Haritoglou C., Kampik A.
Department of Ophthalmology, Ludwig-Maximilians-University, Munich

Purpose: To describe the impact of glucose 5% diluted ICG on the human retina, and to evaluate the ultrastructure of tissue harvested during ICG-assisted surgery for macular hole.
Method: Possible adverse effects of a glucose 5% diluted ICG (Pulsion, Munich and Infracyanine, Paris) solution was evaluated in four donor eyes in an experimental setting using ICG in a concentration of 0.05%. In one eye, the retinal surface was illuminated using the light source of a standard vitrectomy machine, in the other ey, ICG was applied without illumination. The adjacent retina that did not come into contact with the dye served as a control. The retinae were histologically evaluated using light- and electron-microscopy. Additionally, the ultrastructure of the ILM of four eyes that underwent ICG-assisted vitrectomy for a macular hole was examined.
Results: In the postmortem study significant alterations of the inner retina suggesting adverse effects of 0.05% glucose 5% diluted ICG were observed, idependently from the ICG product. A desorganisation of the inner retina and an absence of the internal limiting membrane was seen after the application of the dye with additional illumination. In contrast, no abnormalities were noted after application of the dye alone and in unstained specimens. In specimens of the ILM harvested during vitrectomy, cellular elements were

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