Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Diagnostic Prerequisite for Adult-onset Vitelliform Macular Dystrophy

Renner A. B., Tillack H., Kraus H., Kellner U., Foerster M. H.
Dept. of Ophthalmology, University Hospital Benjamin Franklin, Free University Berlin

Purpose: Adult-onset vitelliform macular dystrophy (AVMD) was first described by Gass (1974). Larger studies using standardized modern morphological and functional diagnostic methods do not exist.
Method: The records of 61 patients with AVMD (ophthalmoscopically defined: a solitary, round, subfoveal, yellow lesion in at least one eye ) were reviewed. The patients were examined at the electrophysiologic laboratory of the UKBF between 1994 and 2002. In particular the results of the following diagnostic methods were analysed: color vision testing (n=40 patients), perimetry (n=26), in vivo fundus autofluorescence (n=11), fluorescein angiography (n=47), EOG (n=11), full-field ERG (n=21), multifocal ERG (n=47). Electrophysiologic tests were performed according to ISCEV standards.
Results: Among the patients, there were 41 females and 20 males. At time of first visit the mean age was 54.7 years (26.4 – 78.1 years). Thirteen patients have been followed for 3.1 years in average (0.9 – 6.1 years). Subjective symptoms, visual loss, color vision deficits and visual field defects showed large variability. In the majority of cases fluorescein angiography presented findings typical for AVMD. Autofluorescence imaging of the fundus revealed in 17/20 eyes an increased level of autofluorescence within the clinically visible yellow lesion compared to the


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