Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Changes of Lens Epithelial Cells in Different Transparency of Lens Layers in Diabetics and Nondiabetics

Schäfer C.1, Lautenschläger C.2, Struck H. G.1
1Department of Ophthalmology and 2Institute of Medical Epidemiology, Biometry and Informatic, Martin-Luther-University Halle-Wittenberg

Purpose: Diabetes mellitus is one of already known risk factors that contribute to cataract formation. It was proven before that there are morphological changes in the epithelium of diabetic cataract lenses. We wanted to know if these alterations are different in dependence of the density in variant lens layers comparing diabetics with nondiabetics.
Method: We examined 97 patients with and without diabetes mellitus type II (70 women, 27 men) at the age of 40 to 100 years who had to undergo a lensextraction because of cataract or in the case of vitrectomy. A clinical subdivision in patients having or not having cataract was made at the slit lamp. In accordance with Scheimpflug photographs (Topcon SL-45) of the anterior eye segment and linear microdensitometric analysis, the 10 different lens layers were identified. During the operation we got the central fragments of the lens capsules which were analysed by light microscopy for the cell parameters cell density (mm2), nuclear area (mm2), nuclear volume (mm3), cell area (mm2) and the nucleus-plasma-ratio.
Results: Concerning the total population the epitheliu


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