Effects of Brinzolamide on Ocular Hemodynamics in Healthy Volunteers
Kaup M., Plange N., Niegel M., Arend O.
Department of Ophthalmology, Aachen University, Aachen
Purpose: A prospective randomized study to evaluate the effects of brinzolamide on retinal and retrobulbar hemodynamics in healthy volunteers.
Method: Thirty volunteers (m: 12, f: 18; 28.3 ± 7.8 years) were examined at baseline and after a 2 weeks treatment with brinzolamide or placebo. Intraocular pressure was measured and automatic static perimetry (Humphrey Field Analyzer, 24-2) and contrast sensitivity (CSV 1000, Vector Vision) were performed. Retrobulbar blood flow velocities (peak systolic and end-diastolic velocity) and resistive indices (RI) of ophthalmic artery, central retinal artery and of temporal and nasal short posterior ciliary arteries were measured by color Doppler imaging (Sonoline Sienna Siemens). In video fluorescein angiograms (scanning laser ophthalmoscope, Rodenstock) arteriovenous passage time (AVP, dilution curves) and peripapillary diameters of retinal arterioles and venoles were measured by means of digital image analysis.
Results: Intraocular pressure was significantly decreased by brinzolamide (p<0.0001). Neither brinzolamide nor placebo changed visual field global indices after treatment. Contrast sensitivity at 3 cycles per degree was significantly higher in the placebo group (p<0.05). Apart from an increase of RI in ophthalmic artery under placebo-treatment (p<0.05) there was no effect in retrobulbar hemodynamics in both groups. Brinzolamide therapy alone resulte
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