Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Metastasis of the Iris – Manifestation of a Known Primary Malignoma?

Schüler A., Stahn J., Schmitz K., Behrens-Baumann W.
Eye-Department, Otto-von-Guericke-University, Magdeburg

Purpose: Primary tumors of the iris are rare and of slow growth in the majority of cases. In case of diagnosis of a rather fast growing tumor of the iris and a known primary malignoma – even if earlier curative therapy has been assumed – hematogenic metastasis of this primary tumor and failure of therapy must be considered.
Method: Case Report: A 60-year old patient presented with a newly developed tumor of the iris of the left eye. One year before, he had undergone surgical resection of a tonsillary squamous cell carcinoma including neck-dissection and postoperative irradiation. Until then, curative treatment of this tumor had been assumed. With the suspected diagnosis of hematogenic metastasis of the known malignoma, diagnostic tumor staging was repeated (CCT, chest x-ray, abdominal sonography, tumor markers). Since no further signs of metastasis could be detected, a biopsy of the iris tumor was performed. Histology revealed metastasis of a moderately differentiated squamous cell carcinoma compatible with the tonsillary carcinoma. Since solitary metastasis of a tonsillary carcinoma to the iris was considered to be extremely unlikely by the ENT-surgeons, a PET was performed to rule out the presence of further micro-metastasis. By this means, a lung mass was detected which was diagnosed as a moderately differentiated bronchial squamous cell carcinoma by bronchoscopic bi

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