Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Retinal Kapillarectasia and Epiretinal Membranes in Neurofibromatosis 2

Feucht M., Richard G. 
Department of Ophthalmology, University of Hamburg

Purpose: To investigate retinal vascular changes and epiretinal membranes as minor ocular findings in neurofibromatosis 2 (NF2).
Method: Through a prospective, non controlled case study, 50 patients with the diagnosis of NF2 underwent a complete ophthalmic examination including fundoscopy and fluorescein angiography.
Results: 36 eyes of 50 patients showed alterations in at least one of the above mentioned investigated parameters. Retinal kapillarektasia was found in 36 eyes intraretinal accumulation of fluorescein due to leakage in 26 eyes and epiretinal gliosis in 24 eyes.
Conclusions: The importance of ocular findings like juvenile cataract, combined pigment epithelial and retinal hamartomas and optic nerve masses for the diagnosis of NF2 is certain. It has also been demonstrated that early diagnosis is crucial in order to prevent deafness from bilateral acusticus tumors. In the present study an accumulation of retinal kapillarektasia, intraretinal leakage and epiretinal gliosis is observed. These ocular findings are suggested to be considered as minor ocular manifastations of NF2.


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