Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

The Pattern of Recurrence of Conjunctival Epithelial Neoplasia

Schilgen G.1, Reinhard T.2, Engelhardt S.1, Sundmacher R.1
1Department of Ophthalmology, Heinrich-Heine University, Dusseldorf
2Eye Hospital, Albert-Ludwigs-University, Freiburg

Purpose: Dysplastic and clearly malignant tumors (carcinoma in situ and invasive carcinoma) of the conjunctiva and the limbus are frequently characterized by untypical clinical presentation, diffuse boundary and by a markedly high rate of recurrence after simple surgical excision. Therefore surgical excision is either combined with various cytostatic treatments or cytostatic treatments are applied several times to control the malignant process. This widespread used therapeutic approach makes it difficult to get a reliable estimation of the efficiency of the individual procedures.
Method: Until January of 2003 the clinical long-term follow-up of 21 patients, who have been treated in our clinic, was evaluated over a mean of 5,7 years.
Results: There was no statistical difference in the likelihood of recurrence based on the histological / cytological grade of the tumor. Approximately every fourth dysplasia, carcinoma in situ and invasive carcinoma reappears after primary treatment once or multiple times. The patients were treated either with simple surgical excision (n=3), cytostatical treatment alone (n=4), or a combination of surgery and various cytostatics (MMC, radiation, kryo, thermo, n=14). A total of five cases of recurrence has been found


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