Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Vitamin A Use in Retinitis Pigmentosa (RP) Patients

Josifova T.1, Ivanovska M.1, Blazevska K.1, Zlateva G.1, Peter S.2
1University Ophthalmology Clinic, Skopje/MAK; 2Augenarztpraxis, Luzern/CH

Purpose: The aim of this study is to show whether the use of vitamin A palmitate in RP patients has advantages over the use of vitamin A in carotinoides.
Method: 23 patients who had used vitamin A palmitate for three years, as well as 31 patients who had used the antioxidant therapy with tabl. of Spirulina pacifica were included in the study. The dosage of vitamin A palmitate was 15.000 IU/day for adults, or 5.000 IU/day, 10.000 IU/day and 15.000 IU/day for children, depending on the age of the child. Tablets of Spirulina pacifica that contain alfa and beta carotinoides and zeaxanthin were taken in daily dosage of 6-10 tablets for adults and 3-6 for chlidren. Supplementation of vit E for adults was in 400 IU/day. Investigation tests of the Visual Acuity, Visual Feeld, Fluorescein Angiography and Electroretinography were performed together with fasting serum A and liver function profile.
Results: After three years of therapy in the A palmitate group, 15/23 (65.2%) had no progression of the disease. Worsening of the condition was detected in 3/23 (13.0%), and intermediate therapy effect increase in 5/23 (21.7%). 18/31 (58.0%) patients treated with carotinoides had the same results as before the therapy. Worsening of the condition was detected in 6/31(19.3%), and intermediate in

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