Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Fluid Shift and Acceleration: Resulting Change of Intraocular Pressure

Alteheld L.1, Draeger J.1, Rumberger E.2, Welsch H.3
1Department of Ophthalmology, Hamburg University; 2Physiological Institute of Hamburg University; 3Aeromedical Institute of the Air Force, Dept. II, Koenigsbrueck

Purpose: Experimental studies in manned spaceflight, parabolic flights and tilting table have revealed a close correlation between resulting fluid shift and intraocular pressure (IOP). Assessment of IOP under rapid change of g-load along the z-axis of the human body has, however, thus far not been achieved.
Method: Using an automatic, gravity-independent self-tonometer IOP of 5 subjects have been taken while g-load was changed from +3 Gz to -1 Gz.
Results: A marked statistically significant increase of IOP could be proved by -1 Gz: 37.2 ± 7,2 mmHg (p£ 0.05) compared to the base line data of 17.3 ± 1.6 mmHg. Our results have shown a minor decrease of IOP at +3 Gz (15.7 ± 2.4 mmHg) which was, however, not statistically significant. At other g-load steps there was little IOP change: 0 Gz: 19.8 ± 2.5 mmHg; +2 Gz: 16.5 ± 2.4 mmHg; +1 Gz after the centrifuge run: 16.6 ± 3.3 mmHg.
Conclusions: Decrease of g-load leads to marked increase of IOP, increase of g-load, however, leads to little change in IOP.


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