Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Glaucoma Detection with Blue-on-yellow (BY) Perimetry Using Regional Analyses

Horn F. K., Dzialach M., Korth M., Jünemann A. M.
University Eye Clinic, Erlangen

Purpose: Aim of this study was to investigate the diagnostic value of BY perimetry with point-wise analyses.
Method: Octopus 101 (grogramm G2) was used to determine localized BY sensitivity in a heterogeneous cohort of subjects: 25 “perimetric” OAG patients (glaucomatous optic disc atrophy and visual field defects in white-on-white perimetry), 52 “preperimetric” OAG patients (glaucomatous optic disc atrophy, no visual field defects in conventional perimetry), 52 patients with OHT, and 40 healthy control subjects. Age range: 30-70 years, AQ: 0.8-1.2, opacity lens meter in the normal range, one eye/subject. All subjects were experienced in conventional white-on-white (WW) perimetry, 35% had earlier BY perimetry. Age normalized defect-values have been calculated for all tests points using the results of an earlier multicenter study. Diagnostic value of tested areas have been judged from the area under the ROC-curve. Differences between localized white-on-white and BY results have been analyzed.
Results: 1. All patient groups showed significantly increased localized BY defects in comparison to conventional WW perimetry in nasal and mid-peripheral clusters. 2. Regional analysis in early glaucomas indicate locations with and locations without diagnostic relevance. Examples show areas under ROC of nasal and temporal test points using WW and BY technique: P20 (nasal) P11(nasal) P14(temp) P25 (temp) WW: 0.69 0.66 0.

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