|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
bFGF-Induced Proliferation of Müller Glial Cells: Dependence on Transactivation of EGF and PDGF Receptor Tyrosine Kinases
Hollborn M., Jahn K., Bringmann A., Wiedemann P., Kohen L.
Purpose: The basic fibroblast growth factor (bFGF) plays a central role in the mediation of responses of the sensory retina to pathogenic events and is one of the main growth factors which stimulates the proliferation of retinal cells in proliferative retinopathies. By using cells of an immortalized human Müller cell line (MIO-M1), we investigated whether the proliferation-stimulating effect of bFGF is mediated by transactivation of other receptor tyrosine kinases and by activation of mitogen-activated protein kinases (MAPKs).