|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
Ischemic Tolerance - A New Pathophysiologic Approach to the Clinical Entity of Partial Central Retinal Artery Occlusion (CRAO)
Junk A. K., Rosenbaum P. S., Engel H. M. , Rosenbaum D. M.
Purpose: Ischemic tolerance has been studied extensively in experimental models of heart and brain ischemia. We have recently demonstrated that this phenomenon occurs in the retina as well and it may, in part, be related to anti-apoptotic mechanisms (IOVS 2002, 43, 3059-66). While there is some clinical evidence of ischemic tolerance in the heart and brain, it is not known whether the same is true in the human retina. The purpose of this study was to determine if prior brief episodes of ischemia protect the retina from subsequent ischemic insults.