Conjunctiva Prophylaxis with a Combined Topical 0.3% Ofloxacin and 5% Iodine Irrigation is Ten-fold More Effective in Reduction of the Bacterial Normal Flora before Cataract Surgery
Miño de Kaspar H.1,2, Kossakiewicz M.2, Singh G.1, Egbert P. R.1, Singh K.1, Blumenkranz M. S.1, Ta C. N.1
1Department of Ophthalmology, School of Medicine, Stanford University, Stanford/USA; 2Department of Ophthalmology, Ludwig-Maximilians-University, Munich
Purpose: To determine the effectiveness of a prophylactic regimen for conjunctival bacterial load reduction prior to cataract surgery.
Method: This prospective study included the application of topical 0.3% ofloxacin (4 times/day for 3 days and 3 times 1 hour prior to surgery) and povidone iodine 5% (PVI) with 45 patients, as their periorbital area was scrubbed and their conjunctival fornices were irrigated with 10 ml solution, 5 minutes prior surgery. Conjunctival samples originate from T0 (baseline, 5 days prior to surgery), T1 (after 3 days of topical ofloxacin), T2 (immediately before surgery) and T3 (at the conclusion of surgery), whereas anterior chamber samples only stem from T2 and T3.
Results: T0 yielded 42/45 positive cultures (93%) with 96 % Gram-positive bacteria. At T1 the bacteria load was reduced 24% to 32/45. At T2 4/45, at T3 2/45 indicated positive growth, that is a reduction of >90% (P<0.001). All anterior chamber aqueous samples (T2/T3) were sterile.
Conclusions: The complete regimen resulted
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