Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Cataract after Stereotactic Irradiation of Intraocular Choroidal Melanoma

Rastegar Z. N.1, Roos H.2, Stefani F.3
1
Hamburg; 2 Institute for Radiological Biology, Munich University; 3Dept. of Ophthalmology, Munich University

Purpose: Cataract is an important effect of exposure to ionizing radiation. In this study, patients with an intraocular choroidal melanoma who had been treated with a Gamma Knife were examined in the years 1998/99. In all cases, only one eye was fully or partly exposed to the radiation. A 50%-isodose with a maximum dose of 50% was applied (maximum dose on the edge of the tumor: 50 Gy). Aim of the study was to investigate whether there are statistically significant differences in the occurrence of lens opacities in the irradiated eyes relative to the non-irradiated eyes.
Method: To analyze the lens opacities, a modified Topcon SL-45 B Scheimpflug camera system of the University of Munich was used in this study. Three Scheimpflug images from three different meridian angles were obtained for each eye. The images were first analyzed quantitatively for opacities anlong the visual axis. These results were then analyzed statistically.
Results: Evaluation of Scheimpflug images distinguishes five anatomical lens regions: I. Anterior capsule, II. Anterior cortex, III. Nucleus, IV. Posterior cortex, V. Posterior capsule. The lenses of 19 patients were examined. The degrees of opacities in the irradiated eyes were compared with the values for the non-irradiated eyes. The statistical analysis o


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