The Vasoprotection of Optic Nerve by Calcium Channel Blockers Therapeutic Possibility in Glaucoma?
Nenciu A., Stefan C., Boeru G., Oprean C.
Spitalul Militar Central Bucureşti, Clinica Oftalmologică, Calea Plevnei nr. 136, Sector 1, Bucureşti, România
Purpose: Evaluation of vasodilator effects elicited by systemic administration of the calcium channel blockers at the site of the optic nerve head following experimental vasospasm.
Method: Prospective, experimental-operational, randomized study spanning 30 days period, on two groups of laboratory animals (rabbits), with 5 rabbits in each group. In both groups, each animal was delivered pure O2 (100 %), at a rate of 1 liter/minute, for 5 minutes at a stretch, eliciting vasospasm. The dihidropiridinic voltage sensitive calcium channel blockers were given in one of the two groups (group A) for entire period (5 mg/kgc/day) and the group B was control group. Transpalpebral color Doppler ultrasonographic examination using an echograph Siemens Versa Plus ( 7.5 Mz linear probe ) was performed. The measurements that revealed hemodynamic events at the site of the arteries of the optic nerve head were performed in the ophthalmic artery, the central retinal artery. The measurements were performed as follows: T0 before the study beginning, T1 after 14 days and T2 after 30 days. The final evaluation was completed with pathologic examination (using hematoxilin-eosin dye and Van Gieson dye). The Anova program was used for statistic analyze.
Results: In group
Zurück | Back