Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

First Clinical Animal Experimentation Experiences and Histological Examinations with Intraocular Lenses (IOL) Consisting of Polyurethan

Amjadi A.1, Jansen M2, Becker J1,. Schrage N.1
1
RWTH Aachen, Dept. of Ophthalmology;  2Geniovis GmbH, Stolberg

Purpose: We aimed to give biological evidence of biocompatibility of a new polyurethane intraocular lens of high refractive index. We compared this material to the biocompatibility of acrylic lenses being in clinical use.
Method: After in vitro proof of biocompatibility of the material we implanted introcular lenses of polyurethane and acryl in each 6 rabbit eyes following standard phakoemulsification in general anesthesia. The animals were examined after one day, one week, 1 and 3 months by means of slit lamp examination. Criteria were status of the cornea, anterior chamber depth, fibrin formation, centric IOL position and damage to the iris. The optical properties and the fixation by means of the haptic was examined.
Results: The implantation procedure of the yet not optimized haptic of the IOL was more difficult as in acrylic IOL. This was due to the large haptic. During the experiment we found a high biocompatibility compared to acrylic IOL. There was posterior capsule fibrosis in both groups somewhat more homogenous in the Polyurethane group. Lens epithelial regrowht was similar in both groups.
Conclusions: In this study we found first the perfect biocompatibility of Polyurethane IOL within the rabbits eye. The


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