Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Modifications of the Extracellular Matrix in Patients with Diabetic Retinopathy

Davidescu F.-L., Niculescu M. 
Clinica Oftalmologică Craiova, Clinic Hospital Nr 1, Craiova

Purpose: The paper proposes the study of the capillaries’ modifications into the bulbar conjunctive at a lot of patients with type 2 diabetes mellitus in different stages of the disease, using classic and immunohistochemical histologic means.
Method: The study was accomplished on bulbar conjunctival fragments intraoperatively removed at patients with type 2 diabetes mellitus, operated for cataract. We constituted 3 lots of patients: patients with cataract and diabetes mellitus, patients with cataract without diabetes mellitus and a control represented by a child operated for ocular wound and intraocular foreign body. The conjunctival fragments were fixed in Lillie solution and processed by the paraffin inclusion technique. With the aid of the fotonic microscopy was studied the general architecture of the tissues in H.E. stain; we followed the type I-III collagen fibbers using the Van Gieson stain and the type IV collagen fibers using the Gömöri stain. Through the Lucia M soft licensed program we determined the external, internal and differential diameter of the conjunctival venous capillary.
Results: The venous capillary wall is thickened in elderly due to the hyperproduction of type IV collagen, that is regular present in the basal membrane structure. At the patients with diabetes mellitus the capillary wall thickening is more important, due to the production of type IV colla

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